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Novartis Iskalizumab for kidney transplantation: not as effective as tacrolimus!

 Last Update: 2021-09-12
 Source: Internet
 Author: User

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Novartis recently announced that it decided to terminate the study after an interim analysis of data from the Phase 2 CIRRUS-1 study (NCT03663335) of the cd40-targeted monoclonal antibody CFZ533 (iscalimab) for the treatment of kidney transplant patients

Analysis shows that compared with tacrolimus treatment, cfz533 treatment is less effective in preventing organ rejection in kidney transplant patients

The cirrus1 study evaluated 418 transplant patients and studied 3 different doses of CFZ533, aiming to evaluate the anti-rejection ability of CFZ533 instead of calcineurin inhibitors (CNI), while having better renal function and better safety.

Novartis is continuing to review data from the CIRRUS-1 study

It is estimated that approximately 3.

CFZ533 (iscalimab) is a new, fully human monoclonal antibody that targets CD40 (cluster of differentiation antigen 40)

In June 2019, Novartis announced the early histological data of CFZ533 in kidney transplantation, indicating that CFZ533 may be more effective than tacrolimus, may extend the durability of the transplanted kidney, and may improve the long-term prognosis of kidney transplant patients

The analysis showed that 60% of kidney transplant patients treated with CFZ533 had normal kidney histology at least 1 year after transplantation, while the proportion of patients treated with tacrolimus was 0

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