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Novarma's leumelocyte-17A (IL-17A) monoantigen Cosentyx (secukinumab) has been approved by the European Commission for the treatment of children and adolescents aged 6-18 with severe plaque-like psoriasis.
: The approval is based on two Phase 3 studies of children and adolescents aged 6-18 years.
in two studies, both low-dose (75-150 mg) and high-dose (75-300 mg) Cosentyx were able to rapidly improve skin symptoms and quality of life in patients.
low dose of Cosentyx can quickly remove skin, with 93% of children reaching Psoriasis Regional Severity Index (PASI) at week 12, 69% reaching PASI 90 in week 12 and PASI 90 at week 24.
addition, 59.5 per cent of children received fully transparent skin (PASI 100) at week 12 and 67 per cent achieved PASI 100 at week 24.
For patients with severe psoriasis, low doses of Consentyx help maintain skin cleanliness up to 52 weeks, with 75% of patients achieving PASI 90 and 44.7% achieving complete remission at 12 weeks.
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