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Non-microbiome-independent effects of antibiotics in a mouse model of nosocomial infection

 Last Update: 2022-08-11
 Source: Internet
 Author: User

Summary

Methicillin Resistant

Staphylococcus aureus(MRSA) is one of the most common causes of hospital-acquired pneumon.

Antimicrobial-resistant (AMR) pathogens cause more than 8 million infections and more than 35,000 deaths annually in the United Stat.

It is responsible for a large number of hospital-acquired and community-acquired infections worldwi.

However, the most common infection in hospital-acquired pneumonia is caused by hospital-acquired strains of MRSA (HA-MRSA), which are very cytotoxic to human neutrophilsin vitroInfection model (2,three

in vivoThese strains exhibit extremely low virulence in commonly used animal models of preclinical infecti.
We found that antibiotic treatment of mice increases susceptibility to HA-MRSA infection, enabling pathogenic studies that rely on animal toxicity or lethal effec.
Antibiotic-treated mice were associated with dehydration and malnutrition, resulting in weight lo.
This mode of antibiotic treatment allows us to deal with clinical isolates that cause lethal infections in humans but show very weak toxicity in tissue culture modelsin vivomouse infection mod.
We expect that the use of this "hospital-adapted" in-hospital mouse model will aid in the identification of virulence factors involved in the pathogenesis of HA-MRSA and other low-virulence pathoge.

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