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Next-Generation 'Synthetic Lethal' Therapy Receives FDA Fast Track Designation

 Last Update: 2022-02-26
 Source: Internet
 Author: User

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Today, Zentalis Pharmaceuticals announced that the U.

Uterine serous carcinoma is a severe and aggressive subtype of endometrial cancer that, although present in less than 10% of patients with endometrial cancer, kills 80% of patients with endometrial cancer

ZN-c3 is a potential "first-in-class" oral inhibitor of WEE1

Image source: Zentalis official website

ZN-c3 has shown promising anticancer activity in clinical trials as a single agent against a variety of solid tumors, with partial responses observed in patients with colorectal cancer, non-small cell lung cancer, ovarian cancer, and uterine serous cancer

Currently, a potential registrational Phase 2 clinical trial in uterine serous carcinoma is underway, and as of May 15 this year, the objective response rate in uterine serous carcinoma patients was 43% (3/7)

▲ZN-c3 exhibits anticancer activity in various solid tumor types (Image source: Zentalis official website)

References:

ZENTALIS PHARMACEUTICALS ANNOUNCES FAST TRACK DESIGNATION GRANTED BY THE US FDA TO ZN-C3 FOR THE TREATMENT OF UTERINE SEROUS CARCINOMA.

(Original abridged)

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