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The transcription factors Atf1 and Rst2 help stabilize each other and bind to open fragments of chromatin structure
.
As the team’s experiment proved, their distance of only 45 base pairs apart is the key to this effect
Source: Tokyo City University
Scientists at Tokyo City University have discovered a unique mechanism in which two transcription factors stabilize the binding of each other to DNA in fission yeast
.
They found that when Atf1 and Rst2 are close enough, they can help to bind to each other stably
The popular DNA helix diagram is a long string of twisted molecular threads that contain all the information needed to create and sustain life
.
What is less well known is how it is neatly packaged and stored in cells: DNA is entwined around a protein structure called histone, forming an elegant, tight arrangement called chromatin.
How transcription factor (TF) binds to chromatin has always been the focus of biomedical research
.
For example, the origin of many cancers can be traced back to when this process went wrong
When yeast cells are starved, we know that the transcription of the fbp1 gene is activated on a large scale by two transcription factors (Atf1 and Rst2)
.
The research team delved into this process and found that these two activations are not only critical to the function of fbp1, but they actually help stabilize each other
Strangely, these TFs are activated by completely independent chemical pathways
.
Therefore, the team's discovery process integrated these routes into a signal "hub
###
Nucleic Acids Research
DOI
10.
