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This issue of "Cell" published an article exploring the mechanism of antidepressant drugs.
Drug source analysis
Drug source analysisThese traditional antidepressants are generally considered to be central 5-HT regulators, the so-called 5-HT imbalance theory.
However, this study is also questioned.
The more core limitation is that these studies are all done under the framework of preclinical animal models.
Of course, it is very easy to find faults as a bystander.