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A protein that plays a key role in regulating allergic airway inflammation could help find better asthma treatments in the future, according to a new study published by the Francis Crick Institute in the UK.
is a common chronic airway inflammation, often leading to recurrent asthma, shortness of breath, chest tightness, cough and other symptoms, seriously affecting the quality of life of patients.
Crick Institute, in collaboration with Imperial College and Genentech, used specially cultured mice in the lab to see how a protein called ABIN-2 affected airway inflammation caused by dust mites.
researchers found that degenerate cells in the lungs of mice capture allergens in the air and activate the immune system. If the "ABIN-2" protein is prevented from playing a key signaling role, dendrine cells secrete more tiny signaling proteins called "CCL24". This protein exacerbates inflammation in the airways and produces mucus, which eventually leads to severe allergic airway inflammation in mice.
Dr. Wilson of Genentek, one of the authors of the study, said the study suggests that severe airway inflammation and asthma may be avoided by regulating the signaling role of the ABIN-2 protein in dendrellation cells.
study has been published in the new issue of the American Journal of Experimental Medicine. (Xinhuanet)
