New progress in catalytic mechanism analysis of defect-enhanced single-atom hydrogen peroxide nanozymes

Nanozymes are a class of nanomaterials with enzymatic properties that can catalyze enzyme substrates under physiological or extreme conditions, have enzymatic reaction kinetics similar to natural enzymes, and can be used as enzyme replacements for human healt.

However, for other catalytic types of nanozymes (such as hydrogen peroxide nanozymes), there are still challenges with unclear structure-activity relationship and low catalytic activit.

Inspired by the concept of single-atom catalysis, a series of highly active single-atom nanozymes have been developed in recent year.

To explore the role of defect structures in the enzymatic catalysis of nanozymes, we prepared a defect-engineered Fe-NC single-atom nanozyme and investigated its catalase-like catalysi.

Excessive production of reactive oxygen species (ROS) can induce abnormal growth of blood vessels, and excessive fundus neovascularization will eventually cause severe retinal vascular lesion.

This study not only proposes new ideas for optimizing the catalytic performance of single-atom nanozymes, but also establishes a synergistic structure-activity relationship between single-atom sites and adjacent defects, which provides an in-depth understanding of the role of defects in nanozyme structures in enzymatic catalysi.

Figure: Defect-engineered highly active hydrogen peroxide nanozyme for the treatment of fundus neovascular disease

Academician Yan Xiyun, researcher Fan Kelong from the Institute of Biophysics, Chinese Academy of Sciences, and Yang Zhenglin, academician from the School of Medicine, Sichuan Provincial People's Hospital and University of Electronic Science and Technology of China are the co-corresponding authors of this articl.

Article link: https://onlinelibrar.

(Contributed by: Van Kelong Research Group)