New progress has been made in the targeted treatment of atherosclerosis

News Agency, Chongqing, January 25 (Reporter Ke Gaoyang) Atherosclerosis and other cardiovascular diseases are a major killer of human health. Chinese researchers have recently made new progress in the field of targeted treatment of atherosclerosis, and the relevant research results have been published as cover articles in the international journal Therapeutic Diagnostics in the field of biomedical sciences.
China Cardiovascular Health and Disease Report 2019, released by the National Cardiovascular Center, shows that the number of cardiovascular disease patients in China exceeds 330 million, and the prevalence and mortality rate are on the rise. Among them, atherosclerosis is a typical chronic inflammatory vascular lesions, which is the main pathological basis of cardiovascular disease. "At present, the use of nano-delivery system for the treatment of atherosclerosis has become a hot topic of research, but the traditional nano-delivery system has a short cycle life, lack of specific targeting, drug release control and other problems." Liao Xiaoling, author of the paper and a professor at Chongqing Institute of Science and Technology, said.
In this way, Liao Xiaoling's research team, in collaboration with Professor Wang Gui of Chongqing University, used a bionic design strategy to wrap macrophage membranes on nanopics, and constructed the bionic nanopic drugs MM/RAPNPs with drug slow release, long-acting blood circulation and active targeting of atherosclerosis drug delivery. The results of animal experiments in small bodies show that the bionic nano-drug can safely and effectively inhibit the development and deterioration of atherosclerosis.
experts believe that this study provides a new design idea for targeted treatment of atherosclerosis, which has important scientific research significance and potential clinical application value.