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New preclinical models could accelerate research into thymic cancer

 Last Update: 2022-09-09
 Source: Internet
 Author: User

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In a study published Aug.

Dr.

The study's lead author, Dr.

The lack of experimental models has hampered research

"We wanted to understand why these tumors occur and how to develop treatments," He said

The team genetically engineered mouse thymus epithelial cells to produce GTF2I L424H mutations and found abnormal development of thymic epithelial cells in young animals

"We think the GTF2I L424H mutation initiates the process of tumor formation," said

He Zhenliang said the next step for the team will be to study how the mutation causes the thymus gland to become cancerous, and what other genetic pathways

"We can use our mouse model to test drugs that target these other genes to find better treatments for thymic epithelial tumors," Dr.

Journal Reference:

Yongfeng He,In-Kyu Kim,Jing Bian,Alexander Polyzos,Dafne Campigli Di Giammartino,Yuwen Zhang,Ji Luo,Maria O.

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