New peptides synthesized by researchers in Yunnan

This report from Kunming Institute of zoology, Chinese Academy of Sciences found that lz1 polypeptide can effectively kill acne related microorganisms, showing better bactericidal and anti-inflammatory effects than clindamycin, and may become a new candidate drug for acne treatment Acne is a chronic inflammatory skin disease that occurs in the hair follicle and sebaceous gland unit It is prone to occur in teenagers and has a great influence on Teenagers' psychology and society Its clinical manifestations are characterized by acne, papule, pustule, nodule and other polymorphous skin lesions At present, it is believed that the process of acne is: the increase of hormone secretion after puberty leads to the failure of effective discharge of a large number of sebum produced by sebaceous glands, which leads to the formation of micro acne In addition to the proliferation of Propionibacterium acnes, it eventually induces and aggravates the inflammatory reaction In clinic, many acne drugs are mainly used for its antibacterial and anti-inflammatory properties, such as peroxybenzoyl, vitamin A acids, antibiotics, etc., mainly antibiotics Because of the side effects of these drugs, which lead to the limitations of their use or produce a lot of drug-resistant strains, it is more and more difficult to treat acne Under the leadership of researcher Lai Ren, the functional proteomics group of natural drugs in the Key Laboratory of animal model and human disease mechanism of Kunming Institute of zoology, Chinese Academy of Sciences designed and synthesized a series of small peptides with only 15 amino acid residues, one of which named lz1 has a strong killing effect on acne related microorganisms The minimum inhibitory concentration of lz1 to Propionibacterium acnes is only 0.6 μ g / ml, while the minimum inhibitory concentration of clindamycin, which is widely used in clinic, to Propionibacterium acnes is 2.3 μ g / ml Lz1 also showed better bactericidal and anti-inflammatory effects than clindamycin in the mouse ear acne model In addition, lz1 peptide has no hemolytic activity and cytotoxicity, and it is very stable in serum Combined with the strong anti-bacterial and anti-inflammatory activity of lz1 and its stability in serum, the researchers believe that lz1 may become a new candidate drug for acne treatment Our reporter Yang Zhigao