New methods to improve neurological dysfunction after stroke were found

, a member of fudan University's Institute of Brain Sciences and a key national laboratory for medical neurobiology, made new progress in the study of neurosurgery repair after stroke. On May 19th, the results of the study were published online in Nature-Newsletter.
stroke is the first cause of death in China. The majority of stroke patients will have the after-effects of half-body inseination and speech difficulties, which bring heavy economic and spiritual burden to society and families. However, how to improve post-stroke neurological dysfunction has been a difficult problem in the international medical community.
conventionally believes that neutrogenic granulocytes can fight exogenetic invading pathogens by forming extracellular trapping nets (NETs). NETs are a mesh structure consisting of DNA in the nuclei or mitochondrials, load proteases and hydrolyzed enzymes. Zhao's team found that stroke causes nexus cells in the brain and blood to produce large amounts of NETs, but they do not protect against brain damage. Through further research, the researchers explained that neithyle NETs are important molecules for inhibiting angiogenesic and remodeling in the brain after stroke. Using a variety of methods and means, such as selective removal of nexual granulocytes, DNA enzymes, PAD4 gene knock-out and drug intervention, the researchers further demonstrated that inhibiting NETs from producing or promoting their degradation can effectively promote angiogenesic and functional remodeling after stroke, and improve impaired nerve function. The findings could provide potential drug targets for the treatment of neurodefunctional disorders after stroke. (Source: Huang Xin, China Science Journal)
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