New methods for improving neurodysfunction after stroke

Zhao Bingxuan, a team at Fudan University's Institute of Brain Sciences and a national key laboratory for medical neurobiology, made new progress in the study of neurofunction repair after strokeThe findings were published online May 19 in Nature-Newsletterstroke is the first cause of death in our countryMost stroke patients will have a half-off and speech difficulties and other varying degrees of sequelae, to the community and families have brought a heavy economic and spiritual burdenHowever, how to improve post-stroke neurodysfunction has been a difficult problem in the international medical communitytradition holds that neutrophils can fight foreign-invading pathogens by forming extracellular traps (NETs)NETs is a mesh structure consisting of DNA within the nucleus or in the mitochondria, loadprotase and hydrolysaseZhao's team found that stroke causes neutrophils in the brain and blood to produce large amounts of NETs, but it has no protective effect on brain damageThrough in-depth research, the researchers explained that neutrophilNE NETs is an important molecule that inhibits the rebirth and remodeling of blood vessels in the brain after strokeUsing a variety of methods and methods, such as selective removal of neutrophils, DNA enzymes, PAD4 gene knockout, and drug intervention, the researchers further studied and demonstrated that inhibiting neTs producing or promoting their degradation can effectively promote vascular rebirth and functional remodeling after stroke, and improve impaired nerve functionThe results may provide potential drug targets for the treatment of post-stroke neurodysfunction(
Bioon.com of Biological Valley)