New method can damage tumor cell 'protection wall'
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Last Update: 2020-06-02
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Source: Internet
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Author: User
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Medicines Network, August 28 (Upi) -- Researchers have found a new way to destroy the "walls of protection" around tumor cells, effectively killing cancer cells, according to a study released by the University of Birmingham on Aug28the school's academic-led research team took samples of myelin-derived inhibition cells (MDSCs) from 200 newly diagnosed cancer patients that can send out large chemical signals to shieldtumorcells, causing the immune system and immunotherapy to fail to function and preventing T-cells that kill tumor cells from being activatedthe team found that in many types of cancer, a protein called CD33 is present on the surface of MDSCs, and an antibody drug already used to treat acute myeloid leukemia can work against CD33, eventually killing MDSCs and restoring the ability of T cells to attack tumor cellsco-author DrFrancis Mussey of the University of Birmingham, one of the authors of the report, said existing immunotherapy often does not kill tumor cells because many times the immune system does not have access to them, and our study shows that this antibody-drug combination with immunotherapy can lead to better outcomes for patientsthe next step the research team plans to use clinical trials to verify the effectiveness and safety of this approach
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