New Drug Delivery Technology: Combination of Supramolecular Solvent and Microemulsion

Article source: Medical Rubik's Cube Pro

As we all know, many insoluble drugs have never entered clinical trials due to poor solubility and difficulty in administration

Recently, the team of Professor Zhang Jiaheng from Harbin Institute of Technology (Shenzhen) and Professor Yanli Zhao from Nanyang Technological University in Singapore published an article on "Advanced Functional Materials" entitled "Enhancing the Solubility and Transdermal Delivery of Drugs Using Ionic Liquid-In-Oil Microemulsions"

IL design

Figure 1 DFT calculations are first performed to study the structural optimization and electrostatic potential (ESP) of ILs based on L-(-)-L-carnitine, and then reduced density gradient (RDG) analysis is performed to prove that hydrogen bonds exist in the IL.

Figure 1.

Preparation process and performance of IL/O ME

Hydrophilic macromolecules cannot easily pass through the stratum corneum into the deep layers of the skin to reach the systemic circulation

Figure 2.

Mechanisms of IL/O MEs to improve drug solubility

IL/O ME with good compatibility has the characteristics of IL and ME

Figure 3.

Skin permeability and biocompatibility of IL/O ME

Figure 4a depicts a schematic diagram of in vitro transdermal penetration into mouse skin in the Franz diffusion cell

Figure 4.

Due to the excellent performance of MME in drug delivery, FITC-insulin/Rosi (MME/FITC-insulin/Rosi) and FITC-insulin/Rosi loaded with MME were used for further evaluation

Figure 5.

summary

Through a combination of theoretical calculations and experimental studies, the supramolecular solvent carrier IL/O ME in this study shows good biological safety and can be used as an enhanced transdermal drug delivery system to increase the solubility of drugs

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Reference materials:

[1] Beibei Lu et al.