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Crohn's disease is an inflammatory disease of the gastrointestinal tract characterized by abnormal responses to microbial and environmental triggers, including alterations in the microbiome dominated by Enterobacteriaceae, especially adherent Escherichia coli Escherichia coli (AIEC), clinical evidence suggests that periods of psychological stress may be associated with exacerbation of Crohn's disease, and disturbance of the gut microbiome may be one of its pathogenesis
Psychological stress promotes the expansion of Enterobacter ileum
Image credit: Shaler, CR, et al.
The key to innate immunity is the protective barrier of the intestinal epithelium, which relies on molecular signals from immune cells to keep harmful microbes out, repairs cell walls and secretes mucus
When the body's innate immune system functions normally, it prevents harmful bacteria from colonizing the body, but when its function collapses, it leaves an opening for pathogens to live in places they would not normally colonize and cause infection disease
Crohn's disease is an inflammatory disorder that causes inflammation, ulcers, and scarring of the body's digestive system.
Taken together, the results of this study suggest that the body's immune regulation may counteract the negative effects of psychological stress on gut immunity, thereby improving or treating disease-related dysbacteriosis
Note: The original text has been deleted
Original source:
Shaler, CR, Parco, AA, Elhenawy, W.
