New discovery! SARS-CoV-2 may infect host intestinal cells and reproduce!

May 26, 2020 /PRNewswire
BIOON/ -- In a recent study published in the international journalScience, scientists from the Hubrecht Institute and others found that the new coronavirus SARS-CoV-2 may infect intestinal cells and replicate in intestinal cellsIn the paper, the researchers used advanced human intestinal culture models to successfully reproduce the SARS-CoV-2 virus in vitro and to monitor cell response to the virus, which may provide a new cell culture model for studying COVID-19, which may explain what researchers observed, i.eabout one-third of COVID-19 patients experience gastrointestinal symptoms such as diarrhea, and researchers can detect the virus in fecal samplespicture source: Maastricht University
COVID-19 patients tend to exhibit a variety of respiratory-related symptoms, such as coughing, sneezing, shortness of breath and fever, which is mainly spread by tiny droplets such as coughing and sneezing However, one-third of patients show gastrointestinal symptoms, such as nausea, diarrhea, etc., and the presence of the virus can also be found in the patient's faeces for a long time after respiratory symptoms are resolved, suggesting that SARS-CoV-2 can also be transmitted through the so-called fecal pathwayAlthough there are significant differences between respiratory and gastrointestinal organs, there are some key similarities, and one particularly interesting similarity is the presence of the ACE2 receptor, which is the key to the virus's entry into the host cell, and the intestines are full of ACE2 receptors, but until now, researchers have not been clear whether the intestinal cells are actually infected and produce virus particlesintestinal organsin this study, researchers asked to determine whether SARS-CoV-2 could directly infect cells in the intestines, and if so, they could replicate in intestinal cells, and then used human intestinal organs to study tiny versions of the human gut that can grow in the laboratory;intestinal cell infection
when researchers added the virus to the organ," SARS-CoV-2 was able to quickly infect organ-like organs, the virus would enter subgroups of intestinal organs, and over time, the number of infected cells would increase, using a technique called electron microscopy (which can observe and image different components of cells), the researchers found that virus particles exist inside and outside the organ cells, because of the outbreak blockade, and the researchers have studied the virus in the home remotelyimage source: Joep Beumer, copyright Hubrecht Institue
then researchers used RNA sequencing techniques to investigate the response of gut cells to viruses, and the results showed that so-called interferon-stimulating genes are activated and are known to fight viral infections, which researchers in later studies focused on, and they wanted to develop new therapies using the resultsIn addition, the researchers cultivated organ-like organs in different conditions that caused ACE2 receptors in cells to be at higher and lower levels, and to the researchers' surprise, they found that at higher and lower levels of ACE2, the virus was able to infect intestinal cells, and that the results could help develop new ways to block the virus from entering host cells Bart Haagmans, the final researcher in the for Future Applications, concluded that this study provides definitive evidence that SARS-CoV-2 can replicate in gastrointestinal cells, however, we do not know whether SARS-CoV-2 in the intestines of PATIENTs with COVID-19 plays a key role in the spread of the disease, so later researchers should study the existence of this possibility carefully, and the results of this paper are in close agreement with other recent studies As a result, gastrointestinal symptoms are found in a large proportion of COVID-19 patients, and the presence of the virus is found in the feces of patients without respiratory symptoms, and patients with gastrointestinal symptoms may need special attention, so later researchers may need to conduct more extensive tests, not only with nasopharyngeal swabs, but also with swabs or faeces samples for SARS-CoV-2 tests at the same time, researchers are continuing to work together to learn more about COVID-19, and are now analyzing the differences between lung and intestinal infections by comparing the lung and intestinal organs of SARS-CoV-2 infections (Bio ValleyBioon.com) References: Mart M Lamers, Joep Beumer, Jelte van der Vaart, et al.
SARS-CoV-2 espressi infects human gutocytes
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Science
01 May 2020 DOI: 10.1126/science.abc1669
2 Coronavirus SARS-CoV-2 infects cells of the