New discovery: "Ruby in North America" can enhance the killing power of antibiotics

The pursuit of delicate women requires a healthy body Only a woman with bright appearance and rich inner health can be called "exquisite" Beauty, beauty and skin health are the dream of all women Cranberries, known as the "Ruby of North America," are popular among women Not only because of its strong taste and high nutritional value, the most important thing is that Proanthocyanidin in cranberry makes some specific bacteria unable to attach to the human body for growth, thus reducing the probability of human infection For women, it is undoubtedly a natural "dietary antibiotic" On May 28, 2019, the research team of McGill University and INRs in Montreal, Canada, published a new study on the resistance of cranberry extract to pathogens in advanced science In this study, the researchers used cranberry extract in combination with antibiotics to study the bacteria that cause urinary tract infection, pneumonia and gastroenteritis The results showed that when Cranberry was used as adjuvant antibiotics, the pathogens were more sensitive to low dose antibiotics What's more, these bacteria don't have resistance to antibiotics The discovery stunned the whole team and made all the participating researchers ecstatic In this regard, the researchers analyzed the mechanism of cranberry extract to improve the sensitivity of bacteria to antibiotics On the one hand, the cranberry extract may loosen the structure of bacterial cell wall, making antibiotics more easily penetrate the bacterial cell wall; on the other hand, the cranberry extract may interfere with the mechanism of bacteria used to pump antibiotics out Researchers have shown that this activity is produced by procyanidins There may be several kinds of proanthocyanidins in the cranberry extract They may be one of them, or they may be the result of several joint actions For this reason, researchers need to do more research in the future to analyze and determine which of them is the most effective with antibiotics, and further clarify the active molecules "We tested it again in the infected insect model The results showed that the synergism of proanthocyanidins and antibiotics could be observed in insects Nathalie tufenkji, research correspondent and professor of chemical engineering at McGill University, said In addition, he is eager to further research on Cranberry to enhance its resistance to pathogens For example, further testing in a subsequent infected animal model will be more powerful in verifying Cranberry's ability to enhance its resistance to pathogens The insect model showed that the synergistic antibacterial effect of proanthocyanidins and antibiotics in vivo the dandelion with diuretic, antibacterial and anti-inflammatory effects on the market and the Rosa roxburghii, which can protect proanthocyanidins to reach the bladder and urethra, all have the ability to enhance the resistance of cranberries against urinary tract infection In the future research, it is hoped that researchers can combine low-dose antibiotics with cranberry, dandelion and Rosa roxburghii or both to analyze their resistance to pathogens, so as to obtain more kinds of "dietary antibiotic" therapy.