New discovery of relationship between hypertriglyceride and atherosclerosis

, professor Liu Guoqing of the Institute of Cardiovascular Research at Peking University found that the activation of endothelial cells in the blood vessels caused by the oxidation of milk particles is the main mechanism that causes the formation of atherosclerosis plaquesThe findings were recently published online in the international lying journal Circulation ResearchThe journal sees the results as a new finding in a study of the relationship between severe hypertriglyceride and atherosclerosisHyperlipidemia is a serious threat to humanhealthdisease, resulting in cardiovasculardisease
caused by death than malignanttumorUnlike western countries, 4/5 of hyperlipidemia in China is hypertlycemia, rather than high cholesterol, and hypertriglycerides is an independent risk factor for atherosclerosisIn order to further explore the pathogenesis of atherosclerosis caused by hypertriglycerides, and through gene target binding cell beneficial mutant gene transfer techniques, the team successfully bred an extremely high triglyceride mouse model with an international lack of lipoprotein lorcosease defects, with plasma triglycerides content exceeding hundreds of times in normal miceSubsequent studies have found that this is the third international study to find that the ApoE gene knockout and LDL receptor gene knockout two mice can develop spontaneous atherosclerosisOnce this result was made public, it attracted international attentionThrough further research, the team confirmed that the oxidation of the milk particles accumulated in the mouse plasma caused by the activation of vascular endothelial cells, which is the main mechanism leading to the formation of atherosclerosis plaquesPrevious international studies have long focused on the oxidative damage of ldl proteinThey also found that the mice, despite the accumulation of triglycerides in the plasma, were still foam cells formed by the accumulation of cholesterol in macrophages In addition, the mice showed increased susceptibility to pancreatitis, central nervous dysfunction, and abnormal blood clotting In cooperation with experts from different disciplines, the Research Group has carried out research at different levels, some of which have achieved phased results (Liu Yuntao)