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New discovery of aluminum adjuvant: nano-aluminosilicate vaccine adjuvant

 Last Update: 2022-06-28
 Source: Internet
 Author: User

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Aluminosilicate has an empty framework structure and a large internal surface area, has a strong Coulomb field and polar effects, and is a commonly used adsorption material

Adjuvant is a kind of substance that can enhance the immune effect of antigen when it is used before or at the same time with antigen.

Researchers have developed a simple and effective "ligand-assisted steric hindrance" synthesis strategy and prepared a series of monodisperse dendritic aluminosilicate nanoparticles with continuously adjustable aluminum coordination number as a new type of nano The adjuvant not only greatly improves the antigen adsorption capacity and cross-presentation efficiency, but also effectively promotes the maturation of immune cells, and at the same time enhances the humoral and cellular immune effects

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