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Cancer stem cells (CSCs) are key drivers of malignancy progression with self-renewal, high metastases and therapy resistance
A research team led by Professor ZHU Tao from the University of Science and Technology of China (USTC), Chinese Academy of Sciences, published a study in the journal Nature Communications, revealing the role of phenotypic plasticity regulated by CSCs in metastatic colonization
The researchers designed an in vitro co-culture system and an in vivo co-implantation system
Further experiments showed that this autonomous inhibition of BCSCs could prompt disseminated tumor cells (DTCs) to exit their dormant state and achieve metastatic colonization
Ferroptosis is a non-apoptotic cell death process caused by metabolic abnormalities and lipid peroxidation
This study sheds light on the role of CSCs-regulated phenotypic plasticity in metastatic colonization and provides a new therapeutic approach to effectively inhibit metastasis
Nature Communications
DOI 10.
