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Image: Researchers at the Cleveland Clinic's Florida Center for Research and Innovation have found that the destruction of cellular structures known as actin cytoskeletons is a "start-up signal" for the body to respond to the virus
Previously, viral genetic material like RNA was thought to be the only requirement for certain sensor molecules living in cells to trigger an immune response — an "alert system"
"This is a fundamental new way to consider how to activate the immune system, and the implications are to lead to widespread antiviral therapy," said Michaela Gack, director of science at FRIC
The cytoskeleton, which is made up of actin, is the structural support of the cell, but also plays a key role
Dr Gack said: "Whether our cellular immune surveillance system can sense this process and trigger an antiviral response is unclear
Despite being around for decades, interest in RNA as the basis for vaccines and treatments has grown
Dr.
Gack's lab studies virus-host interactions at the molecular level, identifying host responses that can play a key role in developing new therapies and vaccines
essay
Actin Cytoskeleton Remodeling Primes RIG-I-like Receptor Activation
