Fat in Alzheimer's disease newcomers has become a new gospel for AD patients

Alzheimer's disease (AD) is a neurodegenerative disease characterized by loss of cognitive ability

Alzheimer's disease (AD) is a neurodegenerative disease characterized by loss of cognitive ability
.
It mainly affects the elderly: about 30% of the population over 85 years old
.
Women are also more likely to develop dementia than men
.
Currently AD has become second only to heart vascular disease, cerebral stroke, the fourth largest death and disease and cancer
.
Heart vascular stroke due AD pathogenesis is very complex, involving many aspects of the pathogenesis, and now there is no treatment can stop or reverse AD of "Grand Theft Auto", only a small part of the therapy may stay its symptoms .
Through previous data, we can find that the most important pathogenic factor for AD is advanced age .
Age plays an important balance between the body's heat production and heat loss .
As we age, our body temperature regulation mechanism may become inefficient .
In addition, scientists have found that the process of AD caused by metabolic disorders in elderly patients is often accompanied by defects in thermoregulation .
So what kind of relationship does AD and thermoregulation defects have? Recently, a review published in the open journal "Ageing Research Reviews" discussed AD and thermoregulation, and used current research progress to summarize potential drug therapies for thermoregulation to alleviate AD .
Fellow hair now brown promote 

 


 
Color fat tissue produces heat, which can improve body temperature to alleviate the symptoms of AD, thus becoming a potential treatment for AD! https://doi.
org/10.
1016/j.
arr.
2021.
101462 The author believes that aging is an important factor in the occurrence of AD.
At the same time, aging of the body will slow down metabolism and cause metabolic diseases such as obesity; on the other hand, these metabolic diseases It will further aggravate the condition of AD patients .
In such a "vicious circle", the body temperature regulation defect, as a key component of poor metabolism, is not to be outdone.
It not only interferes with the energy utilization of the brain, but also aggravates the pathological features of AD introduced above, and plays a role in the overall condition.
"Pushing the flames" role .
The pathological cycle between aging, thermoregulation defects, metabolic disorders and Alzheimer's disease So, how can thermoregulation go "right way"? Here we need to introduce an important part of the human body- brown adipose tissue (BAT), a low-key but vital heat-producing organ .
BAT mainly exists in the human neck, collarbone, kidney and spinal cord .
 
 
  


The PET-CT scan showed that the proportion of brown adipose tissue in the neck and spine of the subject on the left was relatively large.
The Rockefeller University said it was “low-key” because it often weighed only a few grams; it was “important” because When it is activated, it uses sugar and fat in the blood to generate heat in the body
.
This calorie is not only a "magic pill" to improve our body temperature, but also improves blood sugar and blood lipid levels, so that the body's disordered metabolism can be restored to normal! Therefore, promoting BAT thermogenesis, not only can cure patients with AD metabolic problems, but also by improving the body temperature can be slowed three characterization of AD pathology, two-pronged approach, making the potential for AD treatment method!
Stimulating thermogenesis of BAT can improve the pathology of AD So how to stimulate thermogenesis of BAT so as to improve the condition of AD patients? In this article, the author summarized 6 hormones that can improve AD by regulating the function of BAT, including insulin (maintaining brain glucose uptake), adiponectin (promoting neurogenesis), leptin (facilitating memory retention), and fibroblasts Growth factor 21 (improves metabolism), thyroid hormone (improves metabolism) and melatonin (conducive to memory retention) .
Based on the idea that BAT heat production regulates AD, the author believes that new treatment strategies can be developed .
The strategy is divided into two types: non-drug therapy and drug therapy .
Non-pharmacological therapies include: maintaining body temperature by maintaining ambient temperature, and exercise methods that people "like to hear" .
   
 

 
 During exercise, the human body produces a molecule called irisin, which can drive the body's white adipose tissue to transform into brown adipose tissue, thereby promoting the body's heat production, improving body temperature, and achieving the purpose of treating AD
.
Drug therapy is the use of drugs to stimulate thermogenesis of BAT: β3AR agonists are a common method to directly stimulate thermogenesis.
However, whether β3AR agonists can be used in the clinical setting to treat middle-aged and elderly people is still controversial .
In short, body temperature is one of the most basic signs of metabolism in the elderly, and body temperature is approximately inversely proportional to the incidence of AD .
Due to the core role of BAT in thermoregulation, increasing thermogenesis of BAT can restore thermoregulation, improve metabolic parameters (such as insulin resistance), and alleviate the pathological features of AD .
From this point of view, the phrase "life lies in movement" is extremely correct~ References [1] Evidence for brain glucose dysregulation in Alzheimer's disease.
Alzheimers Dement.
2018 Mar;14(3):318-329.
DOI: 10.
1016/j.
jalz.
2017.
09.
011.
[2] Irisin exerts dual effects on browning and adipogenesis of human white adipocytes.
Am J Physiol Endocrinol Metab.
2016 Aug 1;311(2): E530-41.
DOI: 10.
1152/ajpendo .
00094.
 
 

[3] Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing.
Nat Rev Drug Discov.
2020 Sep;19(9):609-633.
DOI: 10.
1038/s41573-020-0072-x.
 

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