New anti-HIV ideas knock on HIV door with drugs to kill infected cells

At present, the scientific community is still looking for ways to solve HIV infection

Although some current treatments can reduce the viral load of HIV, they cannot completely eliminate it

After HIV infects cells, why can't the immune system clear out the virus's nest in advance so that they no longer have the opportunity to release new viruses?

A new study by "Public Library-Pathogens" found that cells originally infected by HIV have been "buyed" and will send signals to other immune cells through molecules on the cell surface to evade immune surveillance

And it is the sugar molecule called sialic acid that performs this task.

Once the two are combined, the receptor sends an inhibitory signal to NK cells to stop them from attacking other cells, so that HIV can continue to replicate without any scruples

The lead author of the new study, Dr.

Now that this direction does not work, researchers began to consider transforming HIV-infected cells

To this end, Dr.

▲Study diagram (picture source: reference [2])

According to the test results, this method can effectively remove the sialic acid on the infected cells.

Researchers pointed out that in the treatment of HIV infection, one way of thinking is "shock and kill.

The author pointed out that this sialidase can be matched with a variety of HIV neutralizing antibodies that have been used in clinical practice, and it can respond to infections with pathogens other than HIV

Note: The original text has been deleted

Reference materials:

[1]Scientists discover sugar molecule on HIV-infected cell plays role in evading immune system.

[2]Opeyemi S.