 Home > Active Ingredient News > Study of Nervous System > Neuron Tsinghua University Xiao Bailong's team found that astrocyte Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive function

Neuron Tsinghua University Xiao Bailong's team found that astrocyte Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive function

 Last Update: 2022-08-20
 Source: Internet
 Author: User

Tags

lysozyme molecular weight

different types candy

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

iNature

It is generally believed that adult brain activity is governed by chemical and electrical conduction mechanisms

On August 12, 2022, Xiao Bailong's team from Tsinghua University published a research paper titled "Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions" online in Neuron, which demonstrated the exploration of mechanically gated Piezo1 channels in astrocytes It is expressed during the process and exploits its mechanosensitivity to mediate mechanically evoked Ca ²⁺ responses and ATP release, thereby establishing Piezo1-mediated mechanochemical transduction in astrocytes

Piezo1 deletion in astrocytes resulted in a significant reduction in hippocampal volume and brain weight, severely impaired (but rescued by ATP) adult neurogenesis in vivo, and abolished the ATP-dependent enhancement of neural stem cell (NSC) proliferation in vitro

Adult brain activity, such as hippocampal neurogenesis and cognitive behavior, is generally thought to be dominated by chemical and electrical transduction mechanisms mediated by chemoreceptors, ligand-gated and voltage-gated ion channels, respectively

—END—The content is [iNature]

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

Related Products

High Quality Pregabalin 99% powder 148553-50-8 -Shaanxi Dideu Medichem Co.Ltd

CAS No.: 148553-50-8

Chemical Grade

$1/KG FOB

Pregabalin (CNS)

CAS No.: 148553-50-8

Pharmacy Grade

$1/KG FOB

Primidone CAS125-33-7

CAS No.: 125-33-7

Pharmaceutical Grade

$100/KG EXW

Hot Tags

united states jobs(223)

jobs united states(236)

1 year treasury(277)

1 year subscription(296)

single use technology(195)

announcements today(81)

ups united states(221)

united states logo(227)

80 20 company(94)

healthy food name(42)

Hot Articles

The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.