NEURON: The biological basis of women's vulnerability to depression has been found
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Last Update: 2020-05-29
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Source: Internet
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Author: User
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Depression is a common disease, and studies have shown that women are twice as likely as menrecently, researchers say long non-coding RNA (lncRNAs), a recently discovered class of regulatory transcripts, represent about one-third of the differential expression genes in the human brain for depression and show complex regional and gender-specific regulatory patternsresearchers found that primate-specific, neuronal-rich gene LINC00473 was lowered in the prefrontal cortex (PFC) in depressed women, but not in menUsing virally mediated gene transfer to express LINC00473 in PFC neurons in adult mice, the researchers simulated a human gender-specific phenotype that induces stress resilience only in female micethis gender-specific pintype is accompanied by changes in female-specific synaptic function and gene expressionIn a study of human neuronal-like cells, researchers found that LINC00473 could act as a CREB effectorcombined, the study identified LINC00473 as a driving substance for female-specific stress resilience, expressing abnormalities in women with depression
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