Neuron Heavy: Key proteins to repair nerve fibers have been 'captured'

previous studies https://doi.org/10.1016/j.neuron.2019.07.007have suggested that neurons in the central nervous system turn off their ability to grow when they find their target cells to complete synaptic build-upHowever, new research suggests that adult nerve cells have the ability to regenerate and repair damage, similar to new nerve cellsThe mechanism for the revival of adult neurons was discovered by a team of scientists at the University of Poland, Professor Frank BradkeBradke said the findings were strikingBut it's also important to say that the growth mechanisms of adult and newborn nerve cells are differentThe researchers found that certain proteins that start to grow in new nerve cells are critical, and that they are key regulators for growth, regardless of developmentThey act on the supporting structure of the cell, triggering dynamic processes, which are also prerequisites for cell growth and regenerationin fact, neurons show growth ability only during embryonic developmentAt this stage, neurons form axons to connect and transmit signalsAs the nervous system develops into adulthood, neurons become less able to grow and regenerate when they are injuredOnly "peripheral" neurons, such as neurons in the arms and legs, have the possibility of repairing damaged connectionsBut if the axons in the spinal cord are cut off, the neurons do not regenerateAs a result, abnormal pathways to nerve impulses can often lead to paralysis and other severe disabilities"For a long time, we've been wondering if it's possible to reactivate the growth potential of nerve cells at an early stage of development, a process that could be a way to trigger regeneration of adult neurons." The study's lead author, Sebastian Dupraz, a postdoctoral researcher on the Bradke team, saidWhat exactly is the key protein for the growth of new nerve cells?in recent years, scientists in Bonn have discovered a variety of factors that affect neuronal growth Proteins in the actin depolymerization factor/sephorin family (actin depolymering factor/cofilins, ADF/cofilin) have been shown to play a key role in neuronal growth During embryonic development, these protein molecules control the formation of cell protrusions, which eventually evolve into axons "In our study, we found that these protein molecules also promote the growth and regeneration of adult neurons after damage Dupraz said in the study, researchers looked at the back root nerve knots in mice and rats, and used time-lapse imaging, invival imaging, and full-load analysis to show that neuronal axon regeneration was caused by an increase in actin turnover Actoprotein molecules belong to a molecular stent that gives cell morphology and stability ADF/cofilin maintains neuronal axon regeneration after spinal cord injury by cutting off actin activity, altering cell structure, controlling the conversion rate of actuatin, and maintaining spinal cord injury these findings reveal the central role of kinetickinsal regulation in the process of axon regeneration, and clarify the core mechanism of post-traumatic axial growth in the central nervous system Therefore, actin or key processes for future regeneration interventions why the researchers chose the back root nerve section because the back root nerve section connects the spinal cord and the surrounding nervous system Nerve cells with the back root nerve section have two axons: a central axon and a peripheral axon It is well known that the surrounding axons are renewable after damage In fact, the central axon can also be regenerated, but only if its peripheral counterpart has been damaged before But as to why such molecular mechanisms exist, Bradke says "we'll study it in the future." the findings of the study lay the foundation for future treatment, which is expected to accelerate post-spinal cord injury treatment But the discovery of neuronal growth and regeneration is a long process, real research understand, landing on the clinical, people have a long way to go, but also believe in science, patience! References: s1 s researcher siresearcher key proteins for the repair of the of the contact of the fiel fibers.