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Multiple sclerosis (MS) is a chronic inflammatory degenerative disease of the central nervous system
.
In the course of the disease evolution of 10-15 years, the progressive irreversible disability that occurs in most patients is largely independent of acute focal inflammatory activities, including recurrence and new MRI damage
.
Neurofilament (NFL) is a biomarker of nerve axon damage.
It increases during the recurrence of RRMS patients and is accompanied by the appearance of new T2/GE MRI lesions.
It returns to baseline within a few months after the acute event, and After receiving DMT, it began to decline
.
In existing cross-sectional studies, the NFL is associated with measures of disease severity, such as the Extended Disability Severity Score (EDS)
.
Recently, some researchers discussed the possibility of serum neurofilament protein (NFL) in relapsing remitting multiple sclerosis (RRMS) patients after applying natalizumab to reflect or predict the progress of the disease
A total of 89 subjects were included in the study
.
The median follow-up time after Natalizumab treatment was 5.
2 years (IQR 4.
- From the first year to the last follow-up, 28/89 (31.
In this study cohort, the NFL failed to capture or predict the progression of the disease, which was largely independent of the clinical or imaging changes of acute focal inflammatory activity
https://n.
neurology.
org/content/early/2021/09/09/WNL.
0000000000012752.
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