-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects both upper and lower motor neurons (UMN) (LMN)
.
For a long time, ALS has been considered to simply affect motor system disorders, and it is now generally believed that cognitive and behavioral changes related to frontal lobe dysfunction are also part of its clinical symptoms
Some video eye tracker studies have shown that different types of abnormal eye movements (OMA) can occur in ALS, which is usually related to changes in the frontal and prefrontal cortex, especially the dorsolateral prefrontal cortex (DLPFC)
.
In this context, OMA may be a potential clinical marker of neurodegeneration other than UMN and LMN
Video Recently, researchers have observed the frequency of OMA in patients with ALS, determined the corresponding OMA pattern, and analyzed its association with sports and cognitive behavioral characteristics
The study is a retrospective controlled study
.
The subject underwent a bedside eye movement assessment to determine the presence and pattern of OMA
- OMA was detected in 10.
5% of the ALS group, while OMA was detected in the cognitively unimpaired group (p=1.
2x10-14) and 11.
4% of the AD group (p=ns)
.
The most common defects are smooth pursuit and abnormal saccades
ALS patients show a series of clinically obvious OMA, and these changes are significantly related to cognitive rather than behavioral changes
https://n.
neurology.
org/content/early/2021/09/09/WNL.
0000000000012774.
long Leave a message here
