 Home > Active Ingredient News > Study of Nervous System > Neurology: Temporal white matter microstructural asymmetry is an effective predictor of memory decline after anterior temporal lobectomy

Neurology: Temporal white matter microstructural asymmetry is an effective predictor of memory decline after anterior temporal lobectomy

 Last Update: 2022-03-05
 Source: Internet
 Author: User

Tags

front matter

multivariate regression analysis

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

Anterior temporal lobectomy (ATL) is an effective treatment for drug-resistant temporal lobe epilepsy (TLE) , but results in memory loss in 30%-60% of patients, and reduced quality of life and functional outcomes
.

Risk factors for memory loss include surgery on the language-dominant hemisphere, better preoperative memory, lower education, older age at seizures, and older age at surgery

To understand the neuroanatomical relationships associated with cognitive outcomes, studies assessed the integrity of the ipsilateral hippocampus (functional adequacy) and the integrity or putative 'functionality' of the contralateral hippocampus (hippocampal reserve)

Recently, researchers have hypothesized that even when HCV is accounted for, asymmetry of deep and superficial white matter microstructure, as an indicator of internal subject reserve and adequacy, can predict the risk of memory decline, with a view to exploring preoperative Whether MTL network microstructure predicts the decline in verbal and nonverbal memory following acute brain injury

In this prospective study, patients with drug-resistant temporal lobe epilepsy were recruited from two epilepsy centers and followed
.

All patients completed preoperative T1 and diffusion-weighted MRI (DMRI) examinations, as well as preoperative and postoperative neuropsychological tests

Forty-two patients with left temporal lobe epilepsy (19 with left temporal lobe epilepsy and 23 with right temporal lobe epilepsy) were included in the analysis
.
Left FA asymmetry in entorhinal SWM independently resulted in decreased prose and associative recall after controlling for preoperative memory scores and HCV (β = -.

46; SE = .
14 and β = -.

Asymmetry of deep and superficial white matter (SWM) integrity of the medial temporal lobe (MTL) before surgery is a strong predictor of postoperative whole-brain memory decline, suggesting that surgical decisions should consider each patient in addition to hippocampal integrity The adequacy and reserve of the WM network

Source: Stasenko A, Kaestner E, Reyes A, et al.

Stasenko A, Kaestner E, Reyes A, et al.
Association Between Microstructural Asymmetry of Temporal Lobe White Matter and Memory Decline After Anterior Temporal Lobectomy [published online ahead of print, 2022 Jan 20].
Neurology.
2022;10.
1212/WNL.
0000000000200047.
doi:10.
1212/WNL.
0000000000200047Leave a message here

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.