-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Middle temporal lobeEpilepsy (mTLE) is one of the most common forms of focal epilepsy, and is related to some pathological changes related to premature aging of the brain
.
For one-third of patients with temporal lobe epilepsy, anti-epileptic drug treatment is ineffective, which leads to the referral of surgical projects aimed at locating and removing the epileptic area
epilepsy
Machine learning models for estimating age from structural MRI scans are promising
.
The increase in the predicted age of the brain (relative to the actual age) indicates accelerated aging or higher cumulative exposure/sensitivity to pathological brain damage, which is contrary to the resilience of the brain
In epilepsy, an increase in BrainAGE has been observed in patients with refractory focal epilepsy and patients with TLE and interictal psychosis
They performed 3D T1-weighted MRI scans on 48 patients with intermittent TLE before and after temporal lobe surgery, and estimated brain age using a Gaussian processes regression model
.
We also examined BrainAGE, which controls changes in brain volume before and after surgery, and compared patients with 37 age- and gender-matched control groups
They found that before the operation, the patient's BrainAGE increased by more than 7 years compared with the control group
.
However, regardless of whether the surgery resulted in complete seizure relief, surgery was associated with a 5-year reduction in average brain AGE
In addition, they also observed a lateral effect, because the brain AGE value of the left MTLE patient after surgery was closer to the value of the control group
.
.
Because the brain AGE value of the MTLE patient on the left after surgery is closer to the value of the control group
Original source:
de Bézenac CE, Adan G, Weber B, Keller SS.
Association of Epilepsy Surgery With Changes in Imaging Defined Brain Age.
Neurology.
Leave a message here
