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Exposure to socioeconomic disadvantage is associated with
early-onset cognitive aging.
As we age, the gradual loss of systemic integrity is thought to be a process
that can mediate this health inequality.
A study published in Neurology explored whether socioeconomic differences in cognitive aging in middle-aged and older adults could be explained
by similar accelerated aging (biological) differences between race, ethnicity, and gender.
Data from a prospective cohort study
of the US Health and Retirement Study DNA Methylation Substudy.
Socioeconomic status (SES) is measured based on the number of years of schooling and household wealth at baseline
.
The extent and rate of aging (biological) is quantified by three DNA methylation measures: phenoAge, grimAge and DunedinpoAm
.
Cognitive aging is measured by repeated longitudinal assessments of immediate and delayed word recall
.
The latent growth curve model estimated participants' memory performance levels and rates
of decline over 2-11 2-20 years of follow-up assessment.
Multiple models were used to assess whether the relationship between SES and memory trajectories was mediated by aging (biological) of subgroups of different races, genders, and
genders.
In a national sample of middle-aged and older adults, measurements of DNA methylation of senescence (biological) correlated
differently with memory trajectories and SES in white, black, and Latino middle-aged and older adults.
These results challenge the hypothesis that DNA methylation biomarkers of aging, developed primarily in white people, can equivalently quantify the aging processes
that affect cognition in black and Latin American middle-aged and older adults.
Source: Avila-Rieger J, Turney IC, Vonk JMJ, et al.
Socioeconomic Status, Biological Aging, and Memory in a Diverse National Sample of Older US Men and Women [published online ahead of print, 2022 Aug].
29].
Neurology.
2022; 10.
1212/WNL.
0000000000201032.
doi:10.
1212/WNL.
0000000000201032
