Neurology: Risk of intrauterine exposure to famine and midlife brain haemorrhage
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Last Update: 2020-05-30
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Source: Internet
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Author: User
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A recent study published in Neurology, an authoritative journal of neurology, explores whether intrauterine exposure to famine between 1959 and 1961 was associated with the risk of cerebral hemorrhage (ICH) in adulthoodin the cohort analysis, the researchers included 97,399 participants in the open-ended study who had no cardiovascular disease or cancer at baseline (2006)The researchers confirmed the ICH case sand through a medical record review and calculated the risk ratio (HR) and 95% confidence interval (CI) of ICH based on intrauterine hunger exposure using the Cox scale risk modelOf the 97,399 subjects, 6.3% (n-6160) experienced great famine before birthin an average of 9.0 years of follow-up (2006-2015), researchers identified 724 cases of ICHAfter adjusting for potential promiscuity, the HR of ICH was 1.99 (95% CI 1.39-2.85) compared to individuals exposed to famine in the palace compared to those who were not exposed to famineWhen the severity of famine exposure and famine was assessed jointly, the adjusted HR of severe lymme-exposed individuals in the palace was 2.99 (95% CI was 1.21-7.39) and the adjusted HR of the individuals exposed to light famine in the palace was 1.94 (95% CI was 1.32-2.84)thus shows that individuals exposed to famine in the palace, especially those exposed to severe famine in the palace, are more likely to develop ICH in middle age, highlighting the role of nutritional factors in this severe susceptibility to brain disease
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