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In the United States, more than 20,000 children experience cardiac arrest each year
Figure 1: Paper cover image
Previously using a modified version of pediatric MRI of the Alberta Stroke Project Early Computed Tomography Score (modASPECTS), demonstrated a close association between the degree of diffusion restriction on clinically obtained MRI scans and neurological outcomes after out-of-hospital cardiac arrest (OHCA).
Quantitative analysis of diffusion MRI can more precisely define the extent of HIBI
ADC declines exponentially with age
Using this, Matthew P Kirschen et al.
The primary research question was whether quantitative diffusion-weighted imaging (DWI) within 7 days of cardiac arrest could predict adverse clinical outcomes in children
They conducted a retrospective study of cardiac arrest patients ≤18 years old with clinically obtained brain MRI within 7 days
ADC images were extracted from diffusion imaging in three directions
Figure 2: The results of the paper
134 patients were analyzed
The sensitivity and specificity of this ADC criterion for adverse outcomes were 0.
The sensitivity, specificity, positive, and negative predictive values of this ADC threshold were 0.
Kirschen MP, Berman JI, Liu H, et al.
