Neurology: Migraine is obviously related to lipoprotein subcomponents

Migraine, particularly migraine with aura (MA), and ischemic stroke and cardiac vascular risk disease (CVD) is associated with increased, prompting researchers to investigate potential links with the traditional CVD risk factors
.

A growing body of evidence supports the unfavorable blood lipid status of migraine patients, including relatively elevated triglycerides (TG), total cholesterol (TC), and low-density lipoprotein (LDL) compared with healthy controls , while high-density lipoproteins (LDL) are relatively high.

Heart blood vessels cholesterol

In addition to the evaluation of conventional lipids, the lipoprotein subcomponents (including particle concentration and Size) can be determined by nuclear magnetic resonance (NMR) spectroscopy,

It provides an additional dimension for analyzing the relationship between lipids and migraine
.

A recent large-scale epidemiological study examined the association of lipoprotein subfractions and lipoproteins with migraine in 8 Dutch cohorts, and concluded that changes in high-density lipoprotein metabolism may be related to migraine status.

In order to avoid some deviations that may occur in observational epidemiological studies, and to further understand the relationship between migraine and lipoprotein subcomponents, genetic methods can be used to confirm the correlation of phenotypes, and to further distinguish between causality and expression.
Common biological mechanisms of type correlation
.

Therefore, Yanjun Guo and others of Harvard University used the data of the Women’s Genome Health Study (WGHS) to assess the phenotypic relationship between migraine and lipoprotein subcomponents, and used the large-scale international headache genetics consortium (IHGC).
The GWAS summary statistics assess migraine (any migraine, MA, and MO) and lipoprotein subfractions.
These data come from WGHS and published data from 14 European ancestry cohorts
.

By using genetic methods applied to the lipoprotein fraction, they aim to explore the biological mechanism between the observed clinical lipid measures and migraine, which may also provide implications for the relationship between migraine and cardiovascular disease

GWAS

Specifically, the phenotypic association between migraine and the amount of 19 lipoprotein subcomponents was evaluated in the Women's Genome Health Study (WGHS, N=22,788)
.

Then, using the International Headache Genetics Consortium (IHGC) comprehensive summary data of migraine (Ncase=54,552, Ncontrol=297,970) and lipoprotein sub-components (N up to 47,713) to study the genetic relationship between these traits

Mendelian randomization (MR) estimates are basically zero, which means that the genetic correlation between migraine and lipoprotein sub-components is determined by pleiotropic rather than causal relationship
.

This means that the genetic correlation between migraine and lipoprotein subcomponents is determined by pleiotropic rather than causal relationship
.

Cross-trait meta-analysis further supports pleiotropy, revealing that there are four loci between migraine and lipoprotein subcomponents (Chr2p21 carries THADA, Chr5q13.
3 carries HMGCR, Chr6q22.
31 Carrying HEY2, Chr7q11.
23 carrying MLXIPL) has obvious shared signals
.

Three of these sites were replicated as migraine in a smaller sample from the British Biobank (P<0.
05)
.

The shared signal of chr5q13.

The significance of this study lies in the discovery: the association between certain lipoprotein subfractions, especially TRLP, and migraine in people of European descent
.

The corresponding shared genetic component may help determine potential targets for future migraine treatment

The association between certain lipoprotein subcomponents, especially TRLP, and migraine in people of European descent

Phenotypic and Genotypic Associations Between Migraine and Lipoprotein Subtractions Neurology Published online October 11, 2021:.
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