Neurology |。 Midlife vascular risk and biomarkers have independent effects on long-term cognitive function

Midlife vascular risk and biomarkers, the effects on long-term cognitive function independently of each other in middle age, vascular risk factors (e.g. hypertension, diabetes) and amyloid, tau protein pathology biomarkers were associated with cognitive decline and an increased risk of clinical symptoms of dementia.
, however, few studies have examined whether these risk factors and markers affect cognitive decline independently or in concert.
, the extent to which vascular risk factors affect cognitive normal individual cognitive processes in the presence of amyloid and tau pathology remains to be seen.
whether vascular risk factors accelerated pathological changes in Alzheimer's disease (AD).
, although some studies have found abnormal levels of AD biomarkers in individuals with higher blood vessel risk in cognitively normal and dementia-free populations, the findings are inconsistent.
, longitudinal studies have failed to find a relationship between vascular risk and amyloid protein changes.
, little is known about how vascular risk affects changes in tau proteins.
is important because there is growing evidence that although amyloid may cause cognitive decline and dementia, this is not absolute.
Putigrew et al., from Hopkins University in the United States, followed 168 cognitively normal middle-aged people (average 56.4 years old) based on biomarkers for Older Controls at Risk for Dementia and measured vascular risk factors and cerebrospinal biomarkers on their baselines.
they used a comprehensive vascular risk score to quantify common vascular risk factors such as high blood pressure, hypercholesterolemia, diabetes, current smoking status, and obesity.
β AD biomarker groups (based on A-beta 1-42), total tau protein (t-tau) and phosphate tau protein (p-tau) were established in the AD biomarkers of the second classification (high and low group) respectively.
, they used linear mixed models to assess changes in cognitive scores (average follow-up 13.9 years) and cerebrospinal biomarkers (average follow-up 4.2 years).
their systematic analysis, they found no synergy between vascular risk scores and AD biomarkers in cerebrospinal fluid and cognitive decline.
, vascular risk scores and biomarkers independently affect cognitive decline.
, the vascular risk score was independent of the level or rate of change of cerebrospinal fluid A beta 1-42, t-tau, or p-tau.
significance of this study is the discovery that vascular risk and biomarkers in middle age are independent of each other and have no synergies for long-term cognitive decline.
, but appropriate measures are still needed to mitigate mid-life vascular risk factors to prevent cognitive decline to some extent.
: Association of midlifevascular risk and AD biomarkers with courgional decline; Corinne Pettigrew, Anja Soldan, Jiangxia Wang, Mei Cheng Wang, Karissa Arthur, Abhay Moghekar, Rebecca F. Gottesman, Marilyn AlbertNeurology Dec 2020, 95 (23) e3093-e3103; DOI: 10.1212/WNL.00000000000010946 Freeman Love Science Source: MedSci Original Copyright Statement: All noted on this website Source: Met Medical Or "Source: MedSci Original" text, images and audio-visual materials, copyrights are owned by Metz Medicine, without authorization, no media, website or individual may reproduce, authorized to reproduce with the words "Source: Mets Medicine".
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