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Neurology: In patients with recurrent multiple sclerosis, age has a greater impact on mortality than disease duration

 Last Update: 2021-06-21
 Source: Internet
 Author: User

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Multiple sclerosis (MS) is a central nervous system of its own immune and demyelinating diseases
.

Its mortality rate is higher than that of the general population matched by age and sex

immunity

The second framework, which is widely used in cancer research but rarely used in multiple sclerosis, uses an additive model, assuming that the mortality rate is the sum of the expected mortality rate and the excess mortality rate (EDR) caused by the disease
.

Describing the dynamics of EDR and the impact of covariates on this dynamic is an important task.

Using this innovative method, Fabien Rollot and others of the University of Lyon in France described the dynamics of EDR in France according to the duration of the disease or the current age, and studied the influence of the age at the onset of multiple sclerosis on these dynamics.
Multiple sclerosis phenotypes were studied separately
.

The second goal is to study the impact of gender on EDR

They used data from 18 French multiple sclerosis specialist centers, which included multiple sclerosis patients living in French metropolises who had clinically onset between 1960 and 2014
.

The life status was updated on January 1, 2016

They found that out of 37524 patients (71% were women), 2883 (7.
7%) deaths were observed and 7.
8% lost follow-up
.

For R-MS patients, there is no excess mortality in the first 10 years after the onset of disease;

After that, regardless of the age at the time of onset, the excess mortality rate increases with the current age
.

Starting from the current age of 70 years, the value of the excess mortality rate tends to be consistent, regardless of the age at the time of onset, which means that the duration of the disease has no more impact

Regardless of the age at the time of onset, the excess mortality rate increases with the current age

Original source:

Effects of Age and Disease Duration on Excess Mortality in Patients With Multiple Sclerosis From a French Nationwide CohortFabien ROLLOT, Mathieu Fauvernier, Zoe Uhry, Sandra Vukusic, Nadine Bossard, Laurent Remontet, Emmanuelle Leray, OFSEP Investigators

Neurology May 2021, 10.

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