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Neurology: Disruption of WM connectivity in frontal and posterior cortical regions in Parkinson's disease may suggest early dementia transformation of PD-MCI

 Last Update: 2022-04-21
 Source: Internet
 Author: User

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Cognitive impairment is one of the most common non-motor symptoms in patients with Parkinson's disease (PD)
.

About 30% of patients have mild cognitive impairment (MCI) in the early stages of PD

Cognitive impairment is one of the most common non-motor symptoms in patients with Parkinson's disease (PD)

Using a 5-year time window to determine whether patients are at imminent risk of PDD transition during follow-up, and to explore the disrupted structural connectivity network associated with early dementia transition in PD-MCI Whether disruption of WM connectivity is associated with risk of PDD transition in newly diagnosed PD-MCI patients and its clinical relevance to frontostriatal deficits
.

diagnosis

Serial cognitive assessments and neuroimaging analysis were performed during follow-up (>5 years) in 75 patients with drug-deficient PD-MCI
.

The patients were divided into PD with dementia (PDD) high-risk group (PDD-H, n=38) and low-risk group (PDD-L, n=37)

Statistics of PD complicated with dementia (PDD) high-risk group (PDD-H, n=38) and low-risk group (PDD-L, n=37)

At baseline assessments, the PDD-H group had lower cognitive performance than the PDD-L group in frontal/executive, visual memory/visuospatial, attention/working memory/language function
.
In a degree-based statistical analysis, the PDD-H group exhibited more severe disruption of WM connectivity in frontal and posterior cortical regions, with 8 central nodes
.
The strength of structural connectivity within the identified sub-networks correlated with composite scores in frontal/executive function domains (γ=0.
393) and risk scores for PDD transition over 5 years (γ=-0.
480)
.

At baseline assessments, the PDD-H group had lower cognitive performance than the PDD-L group in frontal/executive, visual memory/visuospatial, attention/working memory/language function
.

In a degree-based statistical analysis, the PDD-H group exhibited more severe disruption of WM connectivity in frontal and posterior cortical regions, with 8 central nodes

The present study demonstrates that disruption of WM connectivity in frontal and posterior cortical regions associated with frontal/executive dysfunction is associated with early dementia transformation in PD-MCI

This study provides a second type of evidence that disrupted WM connectivity in the prefrontal and posterior cortices is associated with early dementia transformation in PD-MCI

Chung SJ, Kim YJ, Jung JH, et al.

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