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Neurology: Cerebrovascular reactivity is a core feature of cerebral amyloid angiopathy or a biomarker for assessing disease severity and cognitive impairment

 Last Update: 2022-04-22
 Source: Internet
 Author: User

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Cerebral amyloid angiopathy (CAA) Vascular amyloid beta protein (Aβ) Intracerebral hemorrhage (ICH) Cerebral microbleeds (CMBS) Cortical superficial siderosis (CSS)

In CAA patients, a greater burden of hemorrhagic (ICH, CMBS, and CSS) and ischemic (white matter lesions and microinfarcts) consequences was associated with cognitive impairment

Here, we evaluated whole-brain CVR in CAA patients under high carbon dioxide gas stimulation, compared CVR among CAA patients, mild cognitive impairment and AD patients, and healthy controls, and explored MRI markers of CVR and CAA.

Study Design Hypertension

There were 26 patients with cerebral amyloid angiopathy (9 females, age 74.

Decreased cerebrovascular reactivity is a core feature of cerebral amyloid angiopathy and its assessment may provide additional biomarkers for disease severity and cognitive impairment

Beaudin AE, McCreary CR, Mazerolle EL, et al.
Cerebrovascular Reactivity Across the Entire Brain in Cerebral Amyloid Angiopathy [published online ahead of print, 2022 Feb 24].
Neurology.
2022;10.
1212/WNL.
0000000000200136.
doi:10.
1212/WNL.
0000000000200136Leave

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