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Neurology-Autologous hematopoietic stem cell transplantation, treatment of multiple sclerosis, coexistence of efficacy and risk

 Last Update: 2021-08-03
 Source: Internet
 Author: User

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Recently, autologous stem cell transplantation (Autologous haematopoietic stem cell transplantation, AHSCT ) has been increasingly used to treat multiple sclerosis (MS) and other severe self- immune diseases, may be "reset" Based on this program The immune system and the hypothesis of stopping the inflammatory attack

Stem Cell Immunity

Clinical studies have shown that the activity of multiple sclerosis has been greatly inhibited and has long-term clinical stability

In this way, Richard S Nicholas and others of UCL should check the clinical efficacy results and adverse events of the PwMS cohort treated by AHSCT in two leading centers in London, UK, according to standard clinical practice

They conducted a retrospective cohort study of PwMS who received AHSCT treatment in two centers in London, England between 2012 and 2019.

The cohort included 120 Pw MS; 52% had advanced MS (primary or secondary), and 48% had relapsing-remitting MS (RRMS)

Epstein-Barr virus reactivation and monoclonal paraproteinemia are associated with worse PFS

Conclusion: In this real-world cohort, the efficacy results of AHSCT are similar to those reported in the more rigorously selected clinical trial population, although the risk may be higher

In this real-world cohort, the efficacy results of AHSCT are similar to those reported in the more rigorously selected clinical trial population, although the risk may be higher

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