Neurology-Atkins diet to treat glioma, what are the changes in the body?

In view of the low survival rate of current treatment methods, people are increasingly interested in exploring ketogenic diet therapy (KDT) for patients with malignant glioma (MG)
.
In view of the observation that MG cells are overly dependent on the use of glucose to produce energy through glycolysis, a treatment for metabolism is attractive

The classic KDT--high-fat, low-carbohydrate diet--was used as an antidote 100 years ago.
The treatment of epileptic seizures was introduced, but has recently been evaluated in many other neurological diseases
.
A variant, the Modified Atkins Diet (MAD), combines a carbohydrate restriction of 10-20 net grams per day with high fat to provide biological activity while being less restrictive

In this way, Karisa C.
Schreck of Johns Hopkins University and others developed the GLioma Modified Atkins Diet (GLAD) to strictly evaluate the feasibility of eight-week diet intervention for patients with astrocytoma and compare the adherence rate with The whole body and the brain are related to biological activities
.
The G LAD intervention combines MAD with interspersed fasting twice a week to replicate the calorie restriction and ketosis of the preclinical glioma model in a safe manner, and can be used continuously

Systemic indicators including hemoglobin A1c, insulin, and fat body mass decreased significantly, while lean body mass increased
.
MR spectroscopy showed that the ketone body concentration (β-hydroxybutyric acid (bHB) and acetone (Ace)) in the lesion and the contralateral brain increased compared with baseline

The important significance of this study is that it was discovered that although the GLAD dietary intervention is very demanding, it produced meaningful keturia and significant changes in the system and brain metabolism among the participants