Neurology: A two-way association between epilepsy and dementia.

A recent study published in Neurology, an authoritative journal in the field of neurology, aims to assess the risk of epilepsy in participants with dementia in the Framingham Heart Study (FHS) and dementia in people with epilepsy.
researchers analyzed forward-looking data collected in FHS first- and sub-queues.
To determine the risk of epilepsy in participants with dementia and the risk of dementia in participants with epilepsy, the researchers used separate, nested case control designs and matched each case to a control of three age, gender, and FHS queues.
researchers used Cox Proportional Risk Regression Analysis to adjust for gender and age.
a secondary analysis, the researchers looked at the role of educational levels and lipoprotein s4 allotmental gene states in regulating the relationship between epilepsy and dementia.
study looked at 4,906 participants who had epilepsy and dementia information collection and dementia follow-up after the age of 65.
58 of the 660 participants with dementia and 1,980 dementia-free controls had seizures.
comparing epilepsy risk between dementia cases and the control group concluded that HR was 1.82 (95% CI: 1.05-3.16) and p was 0.034.
51 of the 43 epilepsy patients and 129 non-epileptic controls developed dementia.
comparing the risk of dementia between epilepsy cases and the control group concluded that HR was 1.99 (1.11-3.57) and p was 0.021.
In this case group, participants with any high school education had a nearly five-fold increased risk of developing dementia (HR=4.67 (1.82-12.01) and p=0.001) compared to those with the same level of education.
result, there is a two-way association between epilepsy and dementia, and patients with both diseases are nearly twice as likely to develop another disease as those with controls.
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