NeuroImage: Fibrosphere imaging can be used to track epilepsy disease progression

Diffusion magnetic resonance imaging (dMRI) tractography has played a key role in characterizing abnormal brain network reorganization in epilepsy patients
.

However, the accuracy of dMRI tractography is limited due to the complex biophysical properties of white matter tissue

Diffusion magnetic resonance imaging (dMRI) tractography has played a key role in characterizing abnormal brain network reorganization in epilepsy patients

Ezequiel Gleichgerrcht et al.

This study compared network properties obtained by multiple diffusion beam imaging methods (diffusion tensor imaging, diffusion kurtosis imaging, FBI) ​​to assess the pathology of network remodeling in drug-responsive and drug-refractory adult focal epilepsy patients Physiological relevance
.

This study compared network properties obtained by multiple diffusion beam imaging methods (diffusion tensor imaging, diffusion kurtosis imaging, FBI) ​​to assess the pathology of network remodeling in drug-responsive and drug-refractory adult focal epilepsy patients Physiological relevance
.

Image processing flow

Image processing flow

Orientation distribution functions obtained for each diffusion modality (DTI, DKI and FBI) ​​are shown in axial slices corresponding to the blue inset brain regions
.

Orientation distribution functions obtained for each diffusion modality (DTI, DKI and FBI) ​​are shown in axial slices corresponding to the blue inset brain regions
.

The study found that drug-resistant epilepsy was associated with increased brain-wide network dissociation as found by FBI-based tractography
.

The study found that drug-resistant epilepsy was associated with increased whole-brain network dissociation by FBI-based tractography
.

This study validates and confirms the hypothesis that epilepsy is associated with whole-brain network remodeling with increased regional segregation by comparing whole-brain fiber tract connectivity maps using different diffusion patterns, and demonstrates that high b-value diffusion imaging, or FBI, is associated with epilepsy.
changes in epilepsy are very sensitive, especially in patients whose seizures are not controlled by medication
.

In conclusion, the results of this study suggest that FBI tractography may be more sensitive than conventional DTI tractography in assessing microstructural changes associated with intractable epilepsy

This study validates and confirms the hypothesis that epilepsy is associated with whole-brain network remodeling with increased regional segregation by comparing whole-brain fiber tract connectivity maps using different diffusion patterns, and demonstrates that high b-value diffusion imaging, or FBI, is associated with epilepsy.

Ezequiel Gleichgerrcht et al recommend exploring the FBI FBI as a clinically viable alternative to quantify topological changes that can be used to track disease progression and inform clinical outcomes

High b-value diffusion tractography: Abnormal axonal network organization associated with medication-refractory epilepsy

High b-value diffusion tractography: Abnormal axonal network organization associated with medication-refractory epilepsy Leave a message here