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Neonatal ketone bodies determine ovarian aging by regulating follicular reserve

 Last Update: 2022-09-07
 Source: Internet
 Author: User

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Figure: Model of the role of ketone bodies in the formation of the primordial follicle pool

Premature ovarian failure (POA) refers to an early decline in ovarian function; it is the leading cause of infertility in older women and is characterized by a marked reduction in the ovarian reservoir

Scientists from the State Key Laboratory of Reproductive Medicine, Nanjing Medical University and the Center for Reproductive Medicine, Nanjing Drum Tower Hospital found that neonatal serum ketone body production can determine the number of primordial follicle pools by reducing ROS-induced primordial follicle apoptosis during follicular reserve formation in early life and quality

Neonatal exposure to colostrum-enriched dietary lipids transiently stimulates high expression of 3-hydroxy-3-methylglutaryl-CoA synthase 2 (Hmgcs2) in most neonatal mice, including the ovary Rate-limiting enzymes in organs

Another challenge newborns face is higher oxidative stress due to spontaneous breathing

Taken together, this report elucidates that infant nutritional status and associated neonatal ketone body production play an important role in the formation of the primordial follicle pool and further influence normal ovarian capacity in adulthood

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