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NEJM: HSV-1G207 oncolytic virus therapy for high-grade glioma in children

 Last Update: 2021-04-22
 Source: Internet
 Author: User

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High-grade gliomas account for 8%-10% of children's brain tumors.

Childhood Immunization

Recently, researchers conducted a phase I clinical study to evaluate the efficacy and safety of G207 oncolytic virus therapy.

The study adopted a 3+3 design, and biopsy confirmed the participation of children with recurrent or progressive supratentorial brain tumors.

Twelve patients with high-grade glioma received G207 treatment, ranging in age from 7 to 18 years old.

11 patients had imaging, neuropathology or clinical remission, and the average overall survival time of the patients was 12.

Studies have found that intratumoral injection of G207 or combined radiotherapy can significantly alleviate the condition of relapsed or progressive high-grade gliomas in children, and it is well tolerated .

Intratumoral injection of G207 or combined radiotherapy can significantly alleviate the condition of patients with recurrent or progressive high-grade glioma in children, and is well tolerated.

Original source:

Gregory K.

Oncolytic HSV-1 G207 Immunovirotherapy for Pediatric High-Grade Gliomas.
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