Nature's latest study: New coronavirus-specific immune T-cells can also be detected in uninfected populations.

Guide: Beta coronavirus infection induces the body to produce polyspecific and long-lasting cellular immunity to structural proteinsSource: Bio-exploration of new coronal pneumonia caused by the new coronavirus () is still prevalent worldwideCurrently, six coronaviruses are known to infect humans and these viruses trigger antibody and cellular reactions in infected patientsSince previously induced memory cells by pathogens can affect the susceptibility and clinical severity of the virus in subsequent societies, it is extremely important to understand the identifiable memory cells that may exist in the human bodyThe latest research, published in the journal David Duke's National University of Singapore School of Medicine, reveals for the first time the cell response of structural (nuclear shell protein) and non-structural (and) regions during recovery periods, which identify sexist proteins and cellsUnexpectedly, the specific cells were also detected in uninfected populations and the specific cells in the recovered patients were also highly cross-reactiveThis suggests that beta-coronavirus infection induces the body to produce polyspecific and long-lasting cellular immunity to structural proteinsFor studying specific cell researchers, the combined peripheral blood in mild to severely rehabilitated individuals studied the cell's response to selected structural (nuclear shell protein) and non-structural proteins in the protein group, which are highly homologous or even completely homologous between different beta coronavirusesThe researchers found that in almost all individual seisiles, they can identify specific responses in multiple regions targeted at multiple regions and detect clear and/or cell populations to produce gamma and/alphaThe specific response in the recovered patients was then explored by researchers as to whether this acquired immunity could be sustainedThey collected the infected patients from the patients who recovered from the name and tested whether they were still reactive to cells and whether they were cross-reactive to themThe results showed that there were still specific cells in the human body that produced gamma reactions and were concentrated almost exclusively in the regionOne of them produces a clear and robust amplification of reactive cells on the peptide, which is cross-reactive to the peptideThis suggests that viral-specific cells caused by beta-coronavirus infection senile and associated viral infections may be able to prevent or alter the pathology caused by infectionCross-reactions are present in rehabilitative patients in order to explore this possibility The researchers detected their reactive gamma reactions to peptides in unexposed individuals and found that there were places that could detect specific gamma reactions, i.especific cellsFurther studies have found that cells in uninfected people exhibit different patterns of immune advantage, mainly targeting structural proteins and encoded proteins The epistatal representation of specific cells shows that the recognition of protein fragments with low homologous origin with the "common cold" human coronavirus is conservative in animal beta coronaviruses Immune advantage researchers in uninfected individuals say the study helps to understand how existing and specific cells in the general population affect susceptibility and pathogenesis of infection, which is critical to the management of current pandemics Resources: