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This article is original from Translational Medicine Network, please indicate the source for reprinting
Author: TMZHI
Introduction: Tumors often exploit immunosuppressive factors in their tumor microenvironment to impair T cell function, which in turn leads to T cell depletion, resulting in ineffective immunotherapies such as CAR-T cell therapy
On August 24, scientists from the University of California, USA published a study "RASA2 ablation in T cells boosts antigen sensitivity and long-term function" in "Nature".
Doi: 10.
Research Background
01
Adoptive T cell therapy (CAR-T cell therapy) has made major breakthroughs in hematological tumors, and has also made great progress in solid tumors in recent years
research process
02
In order to screen for regulators that can counteract the suppressive effect of T cells, the researchers screened through the genome-wide CRISPR knockout library.
Figure 1.
To further determine the effect of RASA2 on T cells, the researchers analyzed the effect of RASA2 knockout on T cell activation, antigen sensitivity and effector function.
Figure 2.
To further validate the translational potential of these findings, the researchers investigated whether knockdown of RASA2 would improve the therapeutic effect of CAR-T cell therapy in multiple preclinical models
Figure 3.
Significance
03
The poor durability of CAR-T cell therapy has always been a major bottleneck in the application of this treatment in solid tumors.
References:
Carnevale J, Shifrut E, Kale N, et al.
Note: This article is intended to introduce the progress of medical research and cannot be used as a reference for treatment plans
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