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Konzo is a serious, irreversible neurological disease that can lead to paralysis
.
Cassava is the root and basic crop of cassava in the Democratic Republic of Congo and other low-income countries
Eric Vilain, MD, director of the National Children’s Genetic Medicine Research Center, said: “Knowing who is at greater risk can lead to targeted interventions, better handling of cassava, or trying a diversified diet
.
” “Another intervention method.
So far, the exact biological mechanism of the susceptibility and severity of konzo disease is still poorly understood
.
This is the first study to reveal the intestinal microbiota of people whose main food source is toxic cassava
"Given the effects of the environment and malnutrition, the gut microbiota is not the only cause of disease, but it is an essential regulator," said Dr.
Matthew S.
Bramble, a scientist at the National Children’s Association
.
"Simply put, without gut microbes, linamarin and other cyanogenic glycosides pose little risk to humans
In order to understand the impact of harmful survival on the gut microbiota and its relationship with this debilitating multifactorial neurological disease, the researchers used hashing metagenomic sequencing to compare the intestines of 180 children from the Democratic Republic of Congo.
Microbiome profile
.
This method evaluates the diversity of bacteria and detects the abundance of microorganisms and microbial genes in different environments
The samples were collected in Kinshasa, an urban area with diverse diets and no konzo; Masi-Manimba is a rural area where cassava is the main food and the incidence of konzo is low; Kahemba is a cassava as the main food, and konzo is diseased Areas with high rates
.
"This research overcomes many of the challenges of conducting research in low-resource environments," Desire Tshala-Katumbay, MD, PhD in Public Health, FANA, co-senior author and expert scientist of Biomédicale, National Research Center in Kinshasa, Democratic Republic of Congo, Said a professor of neurology at Oregon Health and Science University
.
"This will open up new ways to prevent konzo, a devastating disease of many children in sub-Saharan Africa
In the next step, the researchers will study the siblings in Kahamba's susceptible areas of Kahnsau's disease, where only one sibling was infected with the disease
.
"Studies on siblings will help us control factors that cannot be controlled by other means, such as cassava preparation in the home," said Neerja Vashist, a PhD candidate and research trainee at the National Children’s Association
.
"In this work, each sample has about 5 million DNA reads, so in our follow-up research, we plan to increase the number of reads per sample and the entire research cohort to more than 40 million
Journal Reference :
Matthew S.
