Nature: The brain-fat circuit controls obesity 

Obesity is caused by excessive accumulation of lipids, which can be used as a source of high energy during periods of dietary deprivation
.

Existing studies have shown that signals from sympathetic neurons and immune cells regulate fat cells , thereby promoting the development of adipose tissue biology

Signals from sympathetic neurons and immune cells regulate adipocyte immunity

Recent research progress has shown that the interaction between the nervous and immune systems has become an important regulator of host defense and inflammation
.

However, it is still unclear whether neurons and immune cells cooperate in the brain-body axis to coordinate metabolism and obesity

Recently, researchers described a neuro-interstitial unit that controls the second group of innate lymphocytes (ILC2s), adipose tissue physiology, metabolism, and obesity through the brain-fat circuit
.

Researchers found that sympathetic nerve endings act on adjacent adipocytes through β2-adrenergic receptors to control the expression of glial neurotrophic factor (GDNF) and the activity of ILC2s in gonadal fat

Neural-interstitial unit, which controls the second group of innate lymphocytes (ILC2s), adipose tissue physiology, metabolism and obesity through the brain-fat circuit, and controls the second group of innate lymphatics through the brain-fat circuit Cells (ILC2s), adipose tissue physiology, metabolism and obesity ILC2s autonomously manipulate the GDNF receptor mechanism to cause changes in ILC2 function, energy expenditure, insulin resistance and obesity tendency

ILC2-Intrinsic RET cues control adipose tissue physiology and obesity

ILC2-Intrinsic RET cues control the physiology of adipose tissue and obesity ILC2-Intrinsic RET cues control the physiology of adipose tissue and obesity

In addition, the researchers used retrograde tracking and chemical, surgical, and chemical genetics operations to identify a sympathetic aortic circuit that regulates ILC2s in gonadal fat and is connected to higher-order brain regions, including the paraventricular nucleus of the hypothalamus
.

A sympathetic aortic circuit that regulates ILC2s in gonadal fat and connects to higher-order brain areas, including the paraventricular nucleus of the hypothalamus
.

A sympathetic aortic circuit that regulates ILC2s in gonadal fat and connects to higher-order brain areas, including the paraventricular nucleus of the hypothalamus

 

Original source:

Original source:

Filipa Cardoso et al.

Filipa Cardoso et al.

 

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