-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Picture: Skin cell nucleus (blue) and the outermost layer of the skin (green) stratum corneum, which is the characteristic thickening of atopic dermatitis
Source: MDC Lee Lab
Up to 20% of children and 3% of adults worldwide suffer from eczema, a chronic inflammatory skin disease, also known as atopic dermatitis
Researchers estimate from family and twin studies that two-thirds of eczema susceptibility is due to genetic factors, and environmental factors account for one-third of disease risk
The larger the scale of the research, the greater the chance of finding rare genetic variants
The DNA sequence of two people differs approximately every 1,000 base pairs
The most common genotyping method is to use DNA microarrays-the chip contains as many as millions of snp DNA fragments
Anti-inflammatory enzyme inactivation
"Using this method, we found 11 new variants with a frequency of less than 5% in the population," Marenholz reports
DUSP1 is involved in the inactivation of anti-inflammatory enzymes
New treatments are coming soon
Atopic dermatitis is usually the first allergic disease in infancy, and it may also be the first step in the so-called "atopic march"
Marenholz said optimistically: "The power of genome-wide research lies in the ability to discover previously unknown disease mechanisms-these may become promising targets for new treatments
Article title
Analysis of rare variants in eczema found exon variants in DUSP1, NOTCH4 and SLC9A4
